FITC标记的RTKN蛋白抗体
产品名称： FITC标记的RTKN蛋白抗体
英文名称： Anti-RTKN/FITC
产品编号： HZ-18887R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-RTKN/FITC Conjugated antibody
FITC标记的RTKN蛋白抗体
| 英文名称 | Anti-RTKN/FITC |
| 中文名称 | FITC标记的RTKN蛋白抗体 |
| 别 名 | Rhotekin; Rtkn; RTKN_HUMAN; RTKN1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 63kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RTKN |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Function: Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. Subunit: Interacts via its C-terminal region with the TAX1BP3 PDZ domain. This interaction facilitates Rho-mediated activation of the c-Fos serum response element (SRE). Interacts with SEPT9. Specifically binds to GTP-bound RHOA, RHOB and RHOC and inhibits their GTPase activity. Tissue Specificity: Highly expressed in prostate, moderately in kidney, heart, brain, spleen, testis, placenta, small intestine, pancreas, skeletal muscle and peripheral blood leukocytes, and weakly in ovary, colon and thymus. Weakly expressed in all normal cell lines tested. Overexpressed in various cancer cell lines. Similarity: Contains 1 PH domain. Contains 1 REM (Hr1) repeat. Database links: Entrez Gene: 6242 Human Entrez Gene: 20166 Mouse Entrez Gene: 297383 Rat Omim: 602288 Human SwissProt: Q9BST9 Human SwissProt: Q8C6B2 Mouse SwissProt: Q6V7V2 Rat Unigene: 192854 Human Unigene: 4139 Mouse Unigene: 224634 Rat Unigene: 233799 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码与GTP结合的Rho蛋白相互作用的支架蛋白。该蛋白的结合抑制Rho蛋白的GTP酶活性。这种蛋白质可能干扰活性，GTP结合的Rho转化为非活性的GDP结合形式的RHOGAP。Rho蛋白调节许多重要的细胞过程，包括细胞质分裂、转录、平滑肌收缩、细胞生长和转化。Rho信号转导通路的失调在许多形式的癌症中都有牵连。选择性剪接导致多个转录子变体编码不同的亚型。[ RefSeq，JUL 2008 ]