FITC标记的JM4蛋白抗体
产品名称： FITC标记的JM4蛋白抗体
英文名称： Anti-JM4/FITC
产品编号： HZ-17203R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-JM4/FITC Conjugated antibody
FITC标记的JM4蛋白抗体
| 英文名称 | Anti-JM4/FITC |
| 中文名称 | FITC标记的JM4蛋白抗体 |
| 别 名 | Jena Muenchen 4; JM 4; PRA1 domain family member 2; PRA1 family protein 2; PRAF2; PRAF2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 19kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human JM4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: JM4 is a 178 amino acid endosomal multi-pass membrane protein involved in vesicular trafficking and Endoplasmic reticulum/Golgi transport. As a member of the PRA1 family, JM4 contains four putative transmembrane (TM) domains, interacts with the CC chemokine receptor 5 (CCR5) and colocalizes with Calnexin in the ER and mannose 6-phosphate receptor (CD-MPR) in the Golgi apparatus. While ubiquitously expressed, JM4 has been found at high levels in small intestine, lung, pancreas, spleen, Purkinje cells of the cerebellum and in neuronal cells of the hippocampus, cerebral cortex and lateral ventricles of the brain. JM4 plays a proapoptic role in cerulenin-induced neuroblastoma apoptosis and has been implicated in human cancer. JM4, which serves as a candidate prognostic marker in neuroblastoma, is encoded by a gene that maps to human chromosome Xp11.23 Function: May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in cerulenin-induced neuroblastoma apoptosis. Subcellular Location: Endosome membrane. Tissue Specificity: Strong expression in the brain, small intestine, lung, spleen, and pancreas as well as in tumor tissues of the breast, colon, lung and ovary, with a weaker expression in normal tissues of the same patient. High expression in neuroblastic tumors. Strongly expressed in Purkinje cells and more moderately in cells of the molecular and the granular layers in the cerebellum. Detected in neuronal cells, but not in non-neuronal cells in the cerebral cortex, hippocampus, and lateral ventricles. Similarity: Belongs to the PRA1 family. Database links: Entrez Gene: 11230 Human Entrez Gene: 508703 Cow Entrez Gene: 54637 Mouse Entrez Gene: 367743 Rat SwissProt: Q2KHX3 Cow SwissProt: O60831 Human SwissProt: Q9JIG8 Mouse Unigene: 29595 Human Unigene: 28850 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
JM4是一种178个氨基酸的内体多路膜蛋白，参与囊泡运输和内质网/高尔基体运输。作为PRA1家族的成员，JM4包含四个推测的跨膜（TM）结构域，与CC趋化因子受体5（CCR5）相互作用，并与ER中的Calnexin和高尔基装置中的甘露糖6-磷酸受体（CD-MPR）进行共定位。虽然JM4普遍表达，但在小肠、肺、胰腺、脾脏、小脑浦肯野细胞、海马神经元细胞、大脑皮层和大脑侧脑室中均发现高水平JM4。JM4在Curulin诱导的神经母细胞瘤细胞凋亡中起着促凋亡作用，并参与了人类肿瘤的发生。JM4作为神经母细胞瘤的候选预后标志物，被编码到人类染色体XP1123的基因编码。