FITC标记的吞噬细胞运动蛋白2抗体
产品名称： FITC标记的吞噬细胞运动蛋白2抗体
英文名称： Anti-ELMO2/FITC
产品编号： HZ-20047R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ELMO2/FITC Conjugated antibody
FITC标记的吞噬细胞运动蛋白2抗体
| 英文名称 | Anti-ELMO2/FITC |
| 中文名称 | FITC标记的吞噬细胞运动蛋白2抗体 |
| 别 名 | CED 12; Ced 12 homolog 2; CED 12 homolog A; CED 12A; CED-12; ced-12 homolog 2; CED12; CED12 homolog A; CED12A; ELMO 2; ELMO-2; ELMO2; ELMO2_HUMAN; Engulfment and cell motility 2 (ced 12 homolog, C. elegans); Engulfment and cell motility 2; Engulfment and cell motility protein 2; FLJ11656; hCED 12A; hCED-12A; hCED12A; KIAA1834; PH domain protein CED12A; Protein ced 12 homolog A; Protein ced-12 homolog A. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 83kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ELMO2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Elmo (engulfment and cell motility) proteins share similarity to C. elegans CED-12. The C. elegans genes ced-2, ced-5, ced-10, and ced-12 and their mammalian homologs CRKII, DOCK1, RAC1 and ELMO mediate cytoskeletal rearrangements during phagocytosis of apoptotic cells and cell motility. Elmo1 associates with DOCK 180 and may influence phagocytosis and effect cell shape changes. Src family kinase mediated tyrosine phosphorylation of ELMO1 influences signaling through Elmo1/Crk/DOCK 180 pathways. Elmo2 interacts directly with Rho G in a GTP-dependent manner and forms a ternary complex with DOCK 180 to induce activation of Rac 1. The RhoG-Elmo2-DOCK 180 pathway is required for activation of Rac 1 and cell spreading mediated by integrin, as well as for neurite outgrowth induced by nerve growth factor. Elmo3 acts in assocation with DOCK180 and Crk II and may be required in complex with DOCK180 to activate Rac/Rho small GTPases. Function: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. Subunit: Interacts with the SH3-domain of DOCK1 via its SH3-binding site. Probably part of a complex with DOCK1 and RAC1. Probably part of a complex with DOCK1 and CRK isoform CRK-II. Interacts with ARHGEF16, DOCK4 and EPHA2; mediates activation of RAC1 by EPHA2. Subcellular Location: Cytoplasm. Cytoplasm; cytosol. Membrane. Tissue Specificity: Widely expressed, with a higher expression in skeletal muscle, kidney and placenta. Similarity: Contains 1 ELMO domain. Contains 1 PH domain. Database links: Entrez Gene: 508361 Cow Entrez Gene: 63916 Human Entrez Gene: 140579 Mouse Entrez Gene: 362271 Rat Omim: 606421 Human SwissProt: A4FUD6 Cow SwissProt: Q96JJ3 Human SwissProt: Q8BHL5 Mouse Unigene: 210469 Human Unigene: 35064 Mouse Unigene: 2097 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Elmo（吞噬和细胞运动）蛋白与线虫CIE-12具有相似性。秀丽假丝酵母基因ce-2、ce-5、ce-10和ce-12及其哺乳动物同源物CRKII、DOCK1、RAC1和ELMO在凋亡细胞的吞噬和细胞运动过程中介导细胞骨架重排。ELMO1与DOCK 180相关，并可能影响吞噬作用和影响细胞形状的变化。Src家族激酶介导的ELMO1酪氨酸磷酸化通过ELMO1/CRK/DOCK 180途径影响信号转导。Elmo2以GTP依赖的方式与Rho G直接相互作用，并与DOCK 180形成三元配合物以诱导Rac 1的活化。RhoG-Elmo2-DOCK 180通路在整合素介导的Rac 1激活和细胞扩散以及神经生长因子诱导的神经突起生长中是必需的。ELMO3与DOKK180和CRKⅡ协同作用，可能需要与DOCK180复合物激活RAC/Rho小GTP酶。