FITC标记的转移相关蛋白2抗体
产品名称： FITC标记的转移相关蛋白2抗体
英文名称： Anti-MTA2/FITC
产品编号： HZ-9440R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-MTA2/FITC Conjugated antibody
FITC标记的转移相关蛋白2抗体
| 产品编号 | bs-9440R-FITC |
| 英文名称 | Anti-MTA2/FITC |
| 中文名称 | FITC标记的转移相关蛋白2抗体 |
| 别 名 | Mata1l1; Metastasis associated 1 family member 2; Metastasis associated 1 like 1; Metastasis associated gene 1 like 1; Metastasis associated gene family member 2; Metastasis associated protein 2; Metastasis associated protein MTA 2; Metastasis associated protein MTA2; Mmta2; MTA1 L1 protein; MTA1-L1 protein; MTA1L1; MTA1L1: metastasis-associated 1-like 1; P53 target protein in deacetylase complex; PID; MTA2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 75kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MTA2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: MTA1 is a component of the NURD (nucleosome remodeling and histone deacetylation) complex, which is associated with ATP-dependent chromatin-remodeling and histone deacetylase activity. MTA1 functions in conjunction with other components of NURD to mediate transcriptional repression as it facilitates the association of repressor molecules with the chromatin. Structurally, MTA1 contains a single SH3-binding motif and a zinc finger domain, along with a region similar to the co-repressor protein N-Cor. MTA1 is normally expressed at low levels in various tissues and is more highly expressed in testis. Overexpression of MTA1 correlates with tumor invasion and metastasis in various carcinomas including colorectal, gastrointestinal and breast carcinomas. Elevation of MTA1 levels in these tumors appears to enhance the metastases to lymph nodes, increase mammary cell motility and potentiate growth, and therefore may be an indicator for assessing the potential malignancies of various tumors. A similar protein, MTA2, also designated MTA1-L1 (MTA1-like protein 1), shares more than 55% sequence homology with MTA1 and is ubiquitously expressed. Function: May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins. Subunit: Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with HDAC7, p53/TP53, MINT and MBD3 (By similarity). Subcellular Location: Nuclear Tissue Specificity: Widely expressed. Similarity: Contains 1 BAH domain. Contains 1 ELM2 domain. Contains 1 GATA-type zinc finger. Contains 1 SANT domain. Database links: Entrez Gene: 9219 Human Entrez Gene: 23942 Mouse Entrez Gene: 361724 Rat Omim: 603947 Human SwissProt: O94776 Human SwissProt: Q9R190 Mouse Unigene: 173043 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
MTA1是Nurd（核小体重塑和组蛋白去乙酰化）复合物的一个组成部分，它与ATP依赖的染色质重塑和组蛋白去乙酰化酶活性有关。MTA1与NURD的其他组分共同发挥作用，介导转录抑制，因为它有助于阻遏分子与染色质的结合。在结构上，MTA1包含一个SH3结合基序和一个锌指结构域，以及与共阻遏蛋白N-Co类似的区域。MTA1在各种组织中通常在低水平表达，并且在睾丸中表达更高。MTA1的过度表达与结直肠癌、胃肠道和乳腺癌等各种肿瘤的浸润和转移有关。在这些肿瘤中MTA1水平的升高似乎增强了淋巴结转移，增加了乳腺细胞的运动能力和增强的生长，因此可能是评估各种肿瘤潜在的恶性肿瘤的指标。类似的蛋白质，MTA2，也被命名为MTA1-L1（MTA1样蛋白1），与MTA1共享55%以上的序列同源性，并且被广泛表达。