Anti-LMNA 单克隆抗体-抗体-抗体-生物在线
北京索莱宝科技有限公司
Anti-LMNA  单克隆抗体

Anti-LMNA 单克隆抗体

商家询价

产品名称: Anti-LMNA 单克隆抗体

英文名称: Anti-Lamin A/C Monoclonal Antibody

产品编号: K000143M

产品价格: null

产品产地: 北京

品牌商标: Solarbio

更新时间: 2025-03-06T13:05:44

使用范围: WB IF

北京索莱宝科技有限公司
  • 联系人 : 索莱宝-龚思雨
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Anti-LMNA Monoclonal Antibody 


品牌:solarbio | 货号:K000143M

宿主Mouse
英文名称Anti-LMNA Monoclonal Antibody
别名CDCD1;CDDC;CMD1A;CMT2B1;EMD2;FPL;FPLD;FPLD2;HGPS;IDC;LDP1;LFP;LGMD1B;LMN1;LMNC;LMNL1;MADA;PRO1;Lamin A/C
应用WB IF
稀释比例WB 1:1000. ICC 1:200.
交叉反应Human
蛋白分子量74/65/71/64/63/69kDa
Gene ID4000
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG1
免疫原Purified recombinant human LMNA protein fragments expressed in E.coli.
性状液体
Public Immunogen RangePurified recombinant human LMNA protein fragments expressed in E.coli.
Subcellular LocationsNucleus Nucleus envelope Nucleus lamina Nucleus speckle nucleoplasm
Swiss ProtP02545
克隆号5D12-C6-E9
克隆类型Monoclonal Antibody
背景资料The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.